looks like the future of manylinux will just depend on glibc for compatibility, https://www.python.org/dev/peps/pep-0600/. There may be standardization in nix around how you express required linked libraries. But I think altering the RPATH for everything is somewhat undesirable because the closure size becomes very large

I will defer to @FRidh for this

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It's a nice idea but I don't think it belongs in Nixpkgs, mostly because of limitations. E.g., while you may patch binaries, wheels that have other non-Python dependencies that are not part of the manylinux standard, will still fail. Also, building from source won't work either. Thus I think this is best kept in a separate project.